The Biogenesis of Cytotoxic Granules

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

D Castiblanco, JA Rudd-Schmidt, T Noori, VR Sutton, YH Hung, TWH Flinsenberg, AW Hodel, ND Young, N Smith, D Bratkovic, H Peters, M Walterfang, JA Trapani, AJ Brennan, I Voskoboinik

2022-03-24

Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol..

Lipid specificity of the immune effector perforin

AW Hodel, JA Rudd-Schmidt, JA Trapani, I Voskoboinik, BW Hoogenboom

2021-01-01

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune r..

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

HS Jang, TWH Flinsenberg, P Lacaze, KYT Thia, T Noori, SL Fernando, I Kerridge, M Riaz, JJ McNeil, PA Blombery, JA Trapani, I Voskoboinik

2020-08-01

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

I Voskoboinik, P Lacaze, HSI Jang, T Flinsenberg, SL Fernando, I Kerridge, M Riaz, R Sebra, K Thia, T Noori, EE Schadt, JJ McNeil, JA Trapani

2020-02-20

<jats:p>In a population-based analysis including a large database restricted to patients over age 70, the authors demonstrate that..

Lipid order and charge protect killer T cells from accidental death

JA Rudd-Schmidt, AW Hodel, T Noori, JA Lopez, HJ Cho, S Verschoor, A Ciccone, JA Trapani, BW Hoogenboom, I Voskoboinik

2019-12-01

Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..